Chronic Pancreatitis in Mice Over-expressing Interleukin-1β in the

Pancreatic Secretory Trypsin Inhibitor 1 Reduces the Severity of 1 Chronic Pancreatitis in Mice Over-expressing Interleukin-1β in the 2 Pancreas 3 4 Joelle M.-J. Romac*, Rafiq A. Shahid*, Steve S. Choi, Gamze F. Karaca, Christoph B. 5 Westphalen, Timothy C. Wang, and Rodger A. Liddle 6 7 Department of Medicine, Duke University and Durham VA Medical Centers, North Carolina 8 27710. 9 Department of Medicine and Irving Cancer Research Center, Columbia University Medical 10 Center, New York, 10032. 11 12 * signifies that authors contributed equally to this work and should be considered co-first 13 authors. 14 15 Short title: PSTI reduces pancreatitis in IL-1β transgenic mice 16 17 Abbreviations: IL-1 (interleukin-1), PSTI (pancreatic secretory trypsin inhibitor), MPO 18 (myeloperoxidase) 19 20 Correspondence: Rodger A. Liddle, MD 21 Department of Medicine 22 Box 3913 23 Duke University Medical Center 24 Durham, NC 27710 25 Telephone: (919) 681-6380 26 E-mail: [email protected] 27 28 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (December 15, 2011). doi:10.1152/ajpgi.00287.2011